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BEE VENOM THERAPY in AUTOIMMUNE DISEASEs

May 22, 2010

Thousands of people around the world are successfully using bee stings to cure Chronic Fatigue Syndrome and autoimmune diseases like MS, RA, IBS, etc.   Let’s see how it works.

The human immune system is capable of fighting off infections, healing our body after an injury, detoxifying many poisons, allergens’ etc. and is even central to the pregnancy process of building a baby. What is clearly proven in medical research but unknown to the world in general is that the immune system cannot successfully do anything without being carefully controlled by a separate control system. This control system is independent of the immune system and is responsible for every anti-inflammatory and immune control hormone needed for proper function of the immune system.

Our immune system will switch on in response to infections, injury, toxins and many, many other things but it cannot control its actions or shut its self off. The only thing that our immune system is capable of on its own without controls is the destruction of tissue.

Our immune system is programmed to go into destructive mode any time it activates and then began to heal and repair only as control signals respond and tell the immune system what to do. Autoimmune disease is the result of an activated immune system but inactive or underactive control system. To state that another way, there is nothing wrong with your immune system in autoimmune diseases (the immune system is doing what it is programmed to do) but the control system isn’t doing its job.

So where is the source of immune system controls?

Much of the control comes from the Adrenals which produce about 200 hormones and needed compounds and many are part of the immune system controls. Some control hormones come from the Gonads (the male or female reproductive system) and some from the Thyroid with a few immune control functions elsewhere. Regardless of the source most of these, control compounds are directly controlled by the hormone ACTH from the Pituitary. The rest are controlled by the neurohormone CRH from the Hypothalamus or respond to both ACTH and CRH. ACTH from the Pituitary is under the direct control of CRH from the Hypothalamus.

Without CRH from the Hypothalamus, there isn’t enough ACTH from the Pituitary and without CRH and ACTH there is no control of the immune system.  This means that ALL IMMUNE SYSTEM CONTROLS ARE DEPENDENT ON ENOUGH CRH FROM THE HYPOTHALAMUS TO PROPERLY ACTIVATE THEM AND DO NOT WORK WITHOUT CRH. I call this immune control system the HP>GAT system. The H is for the Hypothalamus/CRH that controls the P (Pituitary/ACTH) and the > means the H (Hypothalamus) and P (Pituitary) control the G (Gonads), the A (Adrenals) and the T (Thyroid) functions that are involved in immune system control.  There are a few people with autoimmune diseases that have proper Hypothalamus/CRH response but damaged Adrenals etc. but these are rare. Almost everyone with autoimmune diseases have a poorly responding Hypothalamus and low blood levels of CRH.

NOTE TO MEDICAL PROFESSIONALS READING THIS: I know you haven’t seen this in any medical book but I have reviewed over 20,000 pieces of research from the best medical research centers in the US and worldwide dealing specifically with this immune control system and the way it works is way beyond proven. I have included over 150 pieces of research in a 200+ page presentation called “THE NEUROENDRINCRINE CAUSE OF AUTOIMMUNE DESEASE AND THE NEUROHOROMONE REPLACEMENT THERAPY CURE”.  Reading this gives the minimum explanations and medical research proof to understand the basics of how this HP>GAT immune control system works.

So how can bee venom help autoimmune disease?

I wish I could pull up one medical report and show you simply how bee venom, blood CRH & the HP>GAT anti-inflammatory/immune control system tie together, but I can’t. No single research group has looked at it yet from the perspective of how all of the connections actually tie together but each step is well documented by multiple reputable researchers.

In order to understand in detail how bee venom works, I would have to show someone in excess of 500 research reports before they could begin to clearly see the inter-relationships. What I am giving is the simplest possible explanation, it is highly complex and I am going to reduce it to a very simple format.

Every poison, toxin, allergen, inflammatory agent, infection and  other type of chemical messenger that can activate the immune system can also activate a receptor in an area of the Hypothalamus called the Para ventricular Nucleus (PVN). These receptors tell the Hypothalamus that there is an immune system activation problem that needs CRH release to control.

To deal with every type of chemical messenger that hits the PVN there are many different types of receptors needed to recognize different problems and each has a different ability to stimulate CRH release. Some things are more capable of causing a release than others and sometimes one type of receptor stops working. The PVN receptors that recognize infection are different than those that recognize the damage of Multiple Sclerosis. Therefore an MS patient may be able to fight infection just fine but still have MS.  It isn’t uncommon for the PVN to lose the ability to respond to some things like inflammatory agents of Rheumatoid Arthritis, yet be able to respond to others like bee venom (they activate different types of receptors in the PVN). Bee venom is a very powerful Hypothalamic CRH blood stimulator that often can be used to get the necessary blood CRH activation of the HP>GAT controls and heal autoimmune disease when the receptors that should respond to the immune system damage of RA or other autoimmune diseases will not work.

Bee venom is one of the few things that I have found so far that has an additional effect not shared by most pollens, toxins, etc. Bee venom not only will stimulate CRH release from the PVN, but it also directly stimulates the release of ACTH from the pituitary, completely separate from CRH. In fact bee venom is a very, very powerful direct stimulator of ACTH from the pituitary.

This means that if the PVN in the hypothalamus is completely nonresponsive and the pituitary is healthy, you will still respond to bee venom. Bee venom will go straight to the pituitary and cause ACTH release. This will do probably 80% of what blood CRH does, which is enough to control inflammation and the repair/rebuilding process.

Bee venom has several more interesting features. First it causes a much larger activation of the HP>GAT axis than is necessary to deal with the venom. Most things just cause enough response to deal with the problem and not a lot of extra. This overreaction of the Hypothalamus to bee venom means there is extra immune control chemicals left over to deal with RA, etc.

Second, it will cause a large release of ACTH each morning for several days after the sting. This drops off at night, thus maintaining a proper day night rhythm. You do not want blood CRH levels high 24 hours a day (this will cause a medical condition called Cushing’s syndrome).

If you do stings 3 or 4 times a week, the HP>GAT/anti-inflammatory system is activated every day and if the response is strong enough it can reverse the disease process.

Bee venom therapy is not the ideal treatment for autoimmune disease, enough stings over time to the same area can do damage. Also sometimes enough stings over time may in some people over power our body’s ability to respond, making us allergic to bees. The ideal autoimmune therapy is to use CRH replacement therapy like they use insulin on diabetics. Unfortunately while CRH is needed by every healthy person in the world and is easy to make, it may be twenty years before anyone has a patented version past the FDA so we can use it to treat autoimmune diseases. In the meantime bee venom can be an effective part of a proper treatment.

Proper treatment for autoimmune diseases should include five things:

  1. Proper nutrition, so our body has enough materials for repair & maintenance.
  1. Heavy supplementation with antioxidants and other things proven to protect the body and make the immune system easier to control. The use of multiple strain (ten or more) types of probiotics has a calming effect on the immune system.
  1. Tobacco and alcohol can drive the inflammatory process out of control; so quit using them or other toxic and inflammatory things.
  1. Proper exercise to keep the body in shape.
  1. Use CRH stimulators like bee venom to boost blood CRH levels.

ALL COMMENTS BY TNYMED FROM THIS PAGE FORWARD ARE IN ITALICS AND ALL OTHER INFORMATION IS DIRECTLY FROM RESEARCH

Included is twenty three research summaries called abstracts that actually show the positive effects of bee venom therapy on animals and humans.

RESEARCH #1

Here is a sample of what can be done by stimulating the HP>GAT axis with bee venom.

Baby pigs like baby humans have poorly working immune system controls. The immune system when controlled properly is far more efficient. Bee venom stimulates the immune system but hyper activates HP>GAT immune system control. This research shows just how effective a properly controlled immune system can be at destroying infection. Notice that bee venom is more effective than standard antibiotics. I have research showing a properly controlled immune system can be just as effective at destroying cancer.

Am J Chin Med.  2003;31(2):321-6.

Effect of apitherapy in piglets with preweaning diarrhea.

Choi SH, Cho SK, Kang SS, Bae CS, Bai YH, Lee SH, Pak SC.

College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univeristy, Cheongju, Korea.

This study was designed to examine the therapeutic effect of honeybee (Apismellifera L.) venom in piglets with bacterial diarrhea Comparison between bee venom- and drug-treated groups was our main concern in the present study. PreWeaning piglets were assigned to treated and non-treated control groups. In the treated group, 47 piglets were acupunctured with the worker honeybee once a day for three consecutive days. Two acupoints, GV-1 (Jiao-chao) and ST-25 (Hai-men), were selected for apitherapy. In the control group, 44 piglets were intramuscularly injected with a standard dose of a known antibacterial drug, colistin sulfate (300,000 IU/kg of body weight), and an antidiarrheal drug (berberine, 2 ml/kg) (berberine is a natural and effective antibiotic available in the health food world) once a day for three consecutive days.

At post-treatment, 90.9% of the control piglets and 93.6% of piglets in the treated group recovered from bacterial diarrhea. Bee acupuncture therapy did not show any side effects such as allergy, intoxication, hemorrhage or infection. It is concluded that bee venom therapy was effective in controlling bacterial diarrhea in preweaning piglets.

PMID: 12856871

RESEARCH #2

Sows and humans have such a huge drop in blood CRH postpartum that the HP>GAT axis often can’t control the immune system. The immune system on the other hand tends to be overactive. THE COMBINATION OF HYPOACTIVE HP>GAT AND HYPERACTIVE IMMUNE SYSTEM PRODUCES THE HIGH INCIDENCE OF RA AND MS FOUND IN WEMON POSTPARTUM. An active but properly controlled immune system is very much more efficient at fighting infections (and cancer) than an uncontrolled hyperactive immune system.

Oligogalactic syndrome is infection of the milk glands similar to mastitis in cows. These sows have very active immune systems but can’t fight infection due to lack of HP>GAT control. Bee venom stimulates blood CRH levels, which activates proper immune system control and makes these sows fight infection more efficiently than penicillin. Here is a prime example of the importance of a properly working HP>GAT axis and what bee venom can do.

Am J Chin Med.  2003;31(1):149-55.

Effect of bee venom treatment in sows with oligogalactic syndrome postpartum.

Choi SH, Kang SS, Bae CS, Cho SK, Pak SC.

College of Veterinary Medicine and Research Institute of Veterinary Medicine

Chungbuk National University, Cheongju 361-763, Korea.

shchoi@cbucc.chungbuk.ac.kr

The objective of this study was to determine the clinico-therapeutic effect of worker honeybee venom in sows with oligogalactic syndrome postpartum.

Comparison between bee venom- and drug-treated groups was our main concern in the present study. Sows after parturition were assigned to bee venom- and drug-treated groups, respectively. In the bee venom-treated group, 22 sows were bee-acupunctured once a day for 3 consecutive days. Honeybees (Apis mellifera L.) forbee acupuncture were about 15 days old after metamorphosis. Live bees were used to sting the acupoints known as yang-ming (ST-18, 1.5 cm lateral to the base of the last two pairs of teats) and jiao-chao (GV- , at the indentation between the base of tail and the anus).

In the drug-treated group, 20 sows were intramuscularly injected with a standard dose of penicillin G (400,000 IU/head) once a day for 3 consecutive days.

On post-treatment day 4, 85.0% of the drug-treated group and 90.9% of the bee venom-treated group recovered from oligogalactic syndrome postpartum. The result suggested that apitherapy using worker honeybee is an effective treatment for sows with oligogalactic syndrome postpartum.

PMID: 12723765

RESEARCH #3

These Russian researchers hit upon something very important and I don’t think they even know the importance of their observation.  They show that bee venom therapy can have a positive effect on lung diseases but they pointed out that the affect was associated with stimulating and normalizing the function of the adrenals.  That is a major and very important observation because the adrenals are part of the HP>GAT system and they respond to blood CRH levels.  The way you get the adrenals to be stimulated and normalize their function is to increase the blood CRH levels, which increases ACTH levels, which stimulates the adrenals.  Also the same increase in blood CRH that helps the adrenals function at higher levels also stimulates the gonads and the thyroid in their anti-inflammatory production.  Although they didn’t notice this, the fact that they noticed the adrenals were stimulated to function better means that the entire HP>GAT system was also stimulated and functioning better. This is direct proof that bee venom is stimulating blood CRH production otherwise they would not have had it normalize the adrenal function.

Lik Sprava.  1995 Mar-Apr;(3-4):155-8.

[The role of apitherapy in the combined treatment of patients with chronic nonspecific lung diseases]

[Article in Russian]

Masterov GD, Nersesian ON.

The authors suggest that apitherapy should be used in the treatment of patients with chronic non-specific pulmonary diseases (ChNPD) in order that it might be more effective. Apitherapeutic complex (bee venom and bee keeping apiculture produce) has been applied to the treatment of 104 ChNPD patients. High effectiveness of apitherapy in a combined treatment of ChNPD patients was demonstrated as was their stimulating and normalizing influence on the function of the adrenals.

PMID: 8819953

RESEARCH #4

Here we see that bee venom is helpful in treating tuberculosis. The observation these researchers make that bee venom normalizes the endocrine system function is extremely important.  What they are observing is that bee venom is boosting the functional capacity of the hypothalamus, pituitary, adrenals, gonads and thyroid; in other words the HP>GAT system.  This is extremely important in tuberculosis because a careful study of tuberculosis will show that the damage done to the human body in tuberculosis is not done by the tuberculosis but is done by the immune system in the area of the tuberculosis.  Tuberculosis stimulates rampant and uncontrolled inflammatory production in the area where it is. This uncontrolled inflammatory production is what destroys the healthy tissue and causes the damage associated with tuberculosis.  In other words it isn’t the tuberculosis that tears up your body and kills you but it is the tuberculosis stimulation of the immune system that makes the immune system destroy the tissues of your body.  Using bee venom to stimulate and normalize the endocrine system boosts anti-inflammatory production. This controls the immune system and makes it stop destroying healthy tissue around the tuberculosis.

Lik Sprava.  1995 Jan-Feb;(1-2):120-2.

[Apitherapy in the combined treatment of patients with pulmonary tuberculosis taking into account the hypophyseal-adrenal system indices]

[Article in Russian]

Masterov GD.

Apitherapy (Venom of bees and apiculture products) was included into combined treatment of 93 in-patients with pulmonary tuberculosis. Apitherapy had a beneficial effect on the organi1sm of tuberculosis patients, manifested by enhancement of the treatment effectiveness and normalization of indices of endocrine system.

It is recommended that the instruction on apitoxinotherapy be amended, in particular, by substantially supplementing the paragraph with indications and contraindications for giving it in active tuberculosis.

PMID: 7483515

RESEARCH #5

These researchers have touched on to many different things to cover here but there are several things I want to point out. 1. If the hypothalamus is responding properly, the brain (through the sympathetic nervous system) has a very strong affect on the anti-inflammatory system. This is obviously the case in these animals, however if the hypothalamus isn’t responding the brain is very limited in the amount of anti-inflammatory production it can get from direct stimulation. This is shown in RA and MS patients that commonly have sympathetic anti-inflammatory stimulation at maximum yet still have low production because of low hypothalamic blood CRH response. Therefore I always refer to the brain as having a minor role in controlling the HP>GAT/anti-inflammatory axis. 2. Bee venom stimulates the brain, the hypothalamus and the pituitary. 3. Blood catecholamines are very important and powerful anti-inflammatory agents (anything that suppresses leukocyte migration and TNF alpha is powerful and important). This is separate from corticosteroids and is something important that would be missed by someone only looking at cortisol production. 4. CRH is a powerful stimulator of catecholamines (In the blood and the brain)

J Neuroendocrinol.  2003 Jan;15(1):93-6.

The anti-inflammatory effect of bee venom stimulation in a mouse air pouch model is mediated by adrenal medullary activity.

Kwon YB, Kim HW, Ham TW, Yoon SY, Roh DH, Han HJ, Beitz AJ, Yang IS, Lee JH.

Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon, South Korea.

Cutaneous electrical or chemical stimulation can produce an anti-inflammatory effect, which is dependent on adrenal medullary-sympathetic activation.

We have previously shown that peripheral injection of bee venom (BV) also produces a significant anti-inflammatory effect that is neurally mediated.

In the present study, we examined whether this anti-inflammatory effect is also dependent on the adrenal gland using the mouse inflammatory air pouch model. Subcutaneous (s.c.) BV injection produced a marked suppression of leucocyte migration and tumour necrosis factor (TNF)-alpha concentration induced by zymosan injection into the air pouch.

The role of the adrenal gland in this suppression was evaluated in adrenalectomized mice. Adrenalectomy significantly reversed the suppression of leucocyte migration and TNF-alpha elevation caused by BV.

Serum concentrations of corticosteroid were increased in mice with zymosan-induced air-pouch inflammation and this increase was reduced by BV administration, suggesting that adrenal corticosteroid release is not involved in mediating the anti-inflammatory effects of BV.

To test this hypothesis, the corticosteroid receptor antagonist (RU486) was administered and found not to affect the BV-induced inhibition of leucocyte migration. By contrast, pretreatment with the beta-adrenergic antagonist propranolol reversed the BV-induced inhibitory effect on leucocyte migration.

These results suggest that the anti-inflammatory effect of s.c. BV administration is mediated in part by the release of catecholamines from the adrenal medulla.

PMID: 12535175

RESEARCH #6

This is an old report and they are only guessing as to why it works, but they do get fairly close and they do show that it works.

Agents Actions.  1979 Jun;9(2):205-11.

Anti-arthritic effect of bee venom.

Chang YH, Bliven ML.

Bee venom, administered subcutaneously, suppressed the development of carrageenan-induced paw edema and adjuvant arthritis in the rat in a dose-related manner. A single dose of bee venom administered subcutaneously the day before or on the day of injection of complete Freund’s adjuvant (CFA) effectively suppressed the development of polyarthritis. This suppressive effect decreased progressively as dosing was delayed. Bee venom was found to be most effective when mixed and injected (sub-plantar) together with CFA, the disease-inducing agent. Similarly, antigens such as egg albumin, when incorporated into CFA, and injected into the hind paw, prevented the development of arthritis. These results suggest that at least two mechanisms are involved in the anti-arthritic action of bee venom: (1) alteration of the immune response, probably via antigen competition, and (2) an anti-inflammatory action via corticosteroids or through an as yet undetermined mechanism.

PMID: 474306

 

RESEARCH #7

The Russians use anything proven to work for anything that it works on and they successfully use lots of bee venom therapy on many things. Here they use the anti-inflammatory affects of bee venom on brain injury.

Zh Nevropatol Psikhiatr Im S S Korsakova.  1990;90(7):53-5.

[Dissociated symptoms of the progressive course of brain injury]

[Article in Russian]

Ludianskii EA.

Hypotension of the cerebrospinal fluid (CSF) was detected in 18% of 856 patients with brain trauma examined in the study. Three syndromes of dissociated hypotension of the CSF were described: (1) at the level of the Magendie-Luschka openings; (2) at the level of the aqueduct of Sylvius; (3) at the level of the third ventricle. Each level of hypotension of the CSF was attended by a specific clinical syndrome. The parameters of the progressive course of the disease made

it possible upon their identification to begin the rehabilitation of patients at the earliest stage which led to a faster compensation.

Special attention was given to apitherapy, phytococtails and instillations of special coctails for controlling the dissociation between CSF hypotension and hydrocephaly. The conducted rehabilitation made it possible to significantly reduce the incidence of crises indicative of the decompensation of brain injury.

PMID: 2175092

 

RESEARCH #8

See it works! 

Ind Med Surg.  1966 Dec;35(12):1045-9.

Standardized bee venom (SBV) therapy of arthritis. Controlled study of 50 cases with 84 percent benefit.

Steigerwaldt F, Mathies H, Damrau F.

PMID: 5332533

 

RESEARCH #9

Like the Russians, the Chinese have many clinical uses for bee venom.

Zhong Yao Cai.  2003 Jun;26(6):456-8.

[Advances in the study of bee venom and its clinical uses]

[Article in Chinese]

Liu H, Tong F.

College of Zoological Sciences, Zhejiang University, Hangzhou 310029, Zhejiang, China.

PMID: 14669739

RESEARCH #10

Here the Koreans have found bee venom works in animals with RA, now if they studied its affect on the HP>GAT axis they would understand why.

Life Sci.  2002 May 31;71(2):191-204.

The water-soluble fraction of bee venom produces antinociceptive and anti-inflammatory effects on rheumatoid arthritis in rats.

Kwon YB, Lee HJ, Han HJ, Mar WC, Kang SK, Yoon OB, Beitz AJ, Lee JH.

Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon, South Korea.

We recently demonstrated that bee venom (BV) injection into the Zusanli acupoints produced a significantly more potent anti-inflammatory and antinociceptive effect than injection into a non-acupoint in a Freund’s adjuvant induced rheumatoid arthritis (RA) model.

However, the precise BV constituents responsible for these antinociceptive and/or anti-inflammatory effects are not fully understood. In order to investigate the possible role of the soluble fraction of BV in producing the anti-arthritic actions of BV acupuncture, whole BV was extracted into two fractions according to solubility (a water soluble fraction, BVA and an ethylacetate soluble fraction, BVE) and the BVA fraction was further tested.

Subcutaneous BVA injection (0.9 mg/kg/day) into the Zusanli acupoint was found to dramatically inhibit paw edema and radiological change (i.e. new bone proliferation and soft tissue swelling) caused by Freund’s adjuvant injection. BVA treatment also reduced the increase in serum interleukin-6 caused by RA induction to levels observed in non-arthriticanimals. In addition, BVA therapy significantly reduced arthritis-induced nociceptive behaviors (i.e. nociceptive scores for mechanical hyperalgesia and thermal hyperalgesia). Finally, BVA treatment significantly suppressed adjuvant-induced Fos expression in the lumbar spinal cord at 3 weeks post-adjuvant injection. In contrast, BVE treatment (0.05 mg/kg/day) failed to show any anti-inflammatory or antinociceptive effects on RA.

The results of the present study demonstrate that BVA is the effective fraction of whole BV responsible for the antinociception and anti-inflammatory effects of BV acupuncture treatment.

Thus it is recommended that this fraction of BV be used for long-term treatment of RA-induced pain and inflammation. However, further study is necessary to clarify which constituents of the BVA fraction are directly responsible for these anti-arthritis effects.

PMID: 12031688

RESEARCH #11

These researchers are proving that bee venom can reduce the affects of arthritis and point out that bee venom injection into an acupuncture point is more affective than bee venom injection into a non-acupuncture point.  While this sounds odd, I have seen lots of research documenting the anti-inflammatory affect of bee venom is stronger if put in an acupuncture site.  The human skin is our body’s first line of defense against infections.  The human skin has it’s own miniature immune system built into it and also a miniature HP>GAT anti-inflammatory system.  This allows the skin to begin responding to infections, toxins, etc. before they get into the blood stream.  Some medical research refers to this anti-inflammatory capability of the skin as the skin HPA axis, because it really does have the elements of the HPA axis built into various sites in the skin.  I believe the reason why an acupuncture point is more effective than a non-acupuncture point is because the site where the anti-inflammatory production capability of the skin is concentrated coincides with the acupuncture points. Too put it differently I think (but I can’t prove) stimulating the anti-inflammatory sites in the skin causes the positive effects and benefits that come from traditional acupuncture and acupressure.  Although I can’t prove it I think the reason why it is more effective to inject in an acupuncture point than a non-acupuncture point is they are putting the bee venom directly into the site where the skin will give the strongest anti-inflammatory response. Once the bee venom hits the blood stream the anti-inflammatory response of the HP>GAT system gets added to the anti-inflammatory response of the skin, therefore you have two anti-inflammatory responses added together. A non-acupuncture point is totally dependent upon bee venom getting to the blood stream for a positive effect.

Pain.  2001 Feb 15;90(3):271-80.

Bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive responses.

Kwon YB, Lee JD, Lee HJ, Han HJ, Mar WC, Kang SK, Beitz AJ, Lee JH.

Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon 441-744, South Korea.

Bee venom (BV) has traditionally been used in Oriental medicine to relieve pain and to treat inflammatory diseases such as rheumatoid arthritis (RA).

While several investigators have evaluated the anti-inflammatory effect of BV treatment, the anti-nociceptive effect of BV treatment on inflammatory pain has not been examined. Previous studies in experimental animals suggest that the therapeutic effect of BV on arthritis is dependent on the site of administration. Because of this potential site specificity, the present study was designed to evaluate the anti-nociceptive effect of BV injections into a specific acupoint (Zusanli) compared to a non-acupoint in an animal model of chronic arthritis.

Subcutaneous BV treatment (1 mg/kg per day) was found to dramatically inhibit paw edema caused by Freund’s adjuvant injection. Furthermore, BV therapy significantly reduced arthritis-induced nociceptive behaviors (i.e. the nociceptive scores for mechanical hyperalgesia and thermal hyperalgesia). These anti-nociceptive/anti-inflammatory effects of BV were observed from 12 days through 21 days post-BV treatment. In addition, BV treatment significantly suppressed adjuvant-induced Fos expression in the lumbar spinal cord at 3 weeks post-adjuvant injection. Finally, injection of BV into the Zusanli acupoint resulted in a significantly greater analgesic effect on arthritic pain as compared to BV injection in to a more distant non-acupoint. The present study demonstrates that BV injection into the Zusanli acupoint has both anti-inflammatory and anti-nociceptive effects on Freund’s adjuvant-induced arthritis in rats. These findings raise the possibility that BV acupuncture may be a promising alternative medicine therapy for the long-term treatment of rheumatoid arthritis.

PMID: 11207399

RESEARCH #12

Here is another report showing the increased effectiveness of using acupoints for bee venom injection. CRH production stimulated by bee venom reduces pain by at least 4 ways. 1. Reducing inflammation that drives the pain. 2. Protecting tissue from further damage. 3. Stimulating production of Endorphins, the body’s natural painkillers. 4. CRH itself is a painkiller and activates endorphin receptors.

Acupoint stimulation using bee venom attenuates formalin-induced pain behavior and spinal cord fos expression in rats.

Kim HW, Kwon YB, Ham TW, Roh DH, Yoon SY, Lee HJ, Han HJ, Yang IS, Beitz AJ, Lee JH.

Department of Veterinary Physiology, College of Veterinary Medicine and School of  Agricultural Biotechnology, Seoul National University, Seoul, South Korea.

In two previous reports, we have demonstrated that injection of bee venom (BV) into an acupoint produces a significant antinociceptive and anti-inflammatory effect in both a mouse model of visceral nociception and a rat model of chronic arthritis.

The present study was designed to evaluate the potential antinociceptive effect of BV pretreatment on formalin-induced pain behavior and it associated spinal cord Fos expression in rats. Adult Sprague-Dawley rats were injected with BV directly into the Zusanli (ST36) acupoint or into an arbitrary non-acupoint located on the back.

BV pretreatment into the Zusanli acupoint significantly decreased paw-licking time in the late phase of the formalin test. In contrast, BV injected into a non-acupoint in the back region did not suppr Ass the paw-licking time. In addition, BV pretreatment into the Zusanli acupoint markedly inhibited spinal cord Fos expression induced by formalin injection. These findings indicate that BV pretreatment into the Zusanli acupoint has an antinociceptive effect on formalin-induced pain behavior.

PMID: 12679565

RESEARCH #13

Here the Koreans find bee venom compares well with prednisolone (an artificially made super version of cortisol), one of the strongest anti-inflammatorys available.

Am J Chin Med.  2002;30(1):73-80.

The effect of whole bee venom on arthritis.

Kang SS, Pak SC, Choi SH.

College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.

This study was performed to assess the clincotherapeutic effect of whole venom of honeybee (Apis mellifera) in adjuvant-induced arthritic rat.

Ninety Sprague-Dawley male rats were injected with complete Freund’s adjuvant (CFA). Adjuvant arthritis was produced by a single subcutaneous injection of I mg Mycobacterium butyricum suspended in 0.1 ml paraffin oil into the right hind paw. Righting reflex was uniformly lost and considered to be the point of arthritis development on day 14 after CFA injection. The experiments were divided into three groups.

When arthritis was developed in the rat, tested groups were administered with prednisolone (10 mg/kg, p.o.) or honeybee venom (one bee, s.c.) every other day for another 14 days. Control group was injected with 0.1 ml of physiological saline solution subcutaneously.

Clinical and hematological values with histopathological findings were observed during the drug administration. In treatment groups, the development of inflammatory edema and polyarthritis was suppressed. No significant differences of hind paw edema volume and lameness score between prednisolone and honeybee venom groups were observed during treatment. White blood cell counts of control group showed leucocytosis that was significantly different from the two treatment groups (p < 0.01). Erosions of articular cartilage and inflammatory cell infiltrations into interphalangeal joint were effectively suppressed in treated groups. In conclusion, whole honeybee venom was found to suppress arthritic inflammation in the rat. This may be an alternative treatment of arthritic agony in humans.

PMID: 12067099

RESEARCH #14

Here we see reduction of pain and improvement of condition in OA with bee venom. OA isn’t caused by damage from an uncontrolled immune system like RA. In OA both the immune and HP>GAT systems are hypoactive, this means normal wear occurs faster than it can be repaired and joints slowly deteriorate. Injecting CRH under the skin will increase immune system CRH (which stimulates the immune system into activity) and raises blood CRH (to give proper control to the immune system for maximum efficiency). THIS COULD STOP OA! —But that is another use for CRH replacement therapy and a subject I will cover in another paper.

The analgesic efficacy of bee venom acupuncture for knee osteoarthritis: a comparative study with needle acupuncture.

Kwon YB, Kim JH, Yoon JH, Lee JD, Han HJ, Mar WC, Beitz AJ, Lee JH.

Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon, Korea.

The aim of this investigation was to determine whether bee venom (BV) administered directly into an acupoint was a clinically effective and safe method for relieving the pain of patients with knee osteoarthritis (OA) as compared to traditional needle acupuncture. We evaluated the efficacy of BV acupuncture using both pain relief scores and computerized infrared thermography (IRT) following 4 weeks of BV acupuncture treatment. We observed that a significantly higher proportion of subjects receiving BV acupuncture reported substantial pain relief as compared with those receiving traditional needle acupuncture therapy. Furthermore, the IRT score was significantly improved and paralleled the level of pain relief.

PMID: 11527062

RESEARCH #15

Research 15 and 16 show increased effectiveness of acupuncture point injection of bee venom, which also shows some of the positive effects that can be gained by CRH replacement therapy.

Visceral antinociception produced by bee venom stimulation of the Zhongwan acupuncture point in mice: role of alpha(2) adrenoceptors.

Kwon YB, Kang MS, Han HJ, Beitz AJ, Lee JH.

Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon 441-744, South Korea.

The goal of the present study was to determine whether bee venom (BV) injection into the Zhongwan acupoint (CV12), compared to injection into a non-acupoint, produced antinociception in an acetic acid-induced visceral pain model.

This was accomplished by injecting BV subcutaneously into the Zhongwan acupoint or into a non-acupoint 30 min before intraperitoneal injection of acetic acid in ICR mice. BV injection into the acupoint produced a dose dependent suppression of acetic acid-induced abdominal stretches and of acetic acid-induced Fos expression in the spinal cord and the nucleus tractus solitarii. In contrast BV injection into the non-acupoint only produced antinociception at the highest dose of BV tested.

Naloxone pretreatment did not alter the antinociceptive effect of BV acupoint injection on the abdominal stretch reflex. On the other hand, pretreatment with the alpha 2-adrenoceptor antagonist, yohimbine completely blocked the antinociceptive effect of BV acupoint injection. These results imply that BV acupoint stimulation can produce visceral antinociception that is associated with activation of alpha 2-adrenoceptors, but not with naloxone-sensitive opioid receptors.

PMID: 11457577

RESEARCH #16

Acupunct Electrother Res.  2001;26(1-2):59-68.

Antinociceptive effects of bee venom acupuncture (apipuncture) in rodent animal models: a comparative study of acupoint versus non-acupoint stimulation.

Kwon YB, Kang MS, Kim HW, Ham TW, Yim YK, Jeong SH, Park DS, Choi DY, Han HJ,

Beitz AJ, Lee JH.

Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon, South Korea.

From a clinical perspective, the alternative forms of acupoint stimulation including electroacupuncture, moxibustion and acupressure appear to have more potent analgesic effects than manual needle acupuncture. Bee venom (BV) injection has also been reported to produce persistent nociceptive stimulation and to cause neuronal activation in the spinal cord.

In previous study, we observed that BV stimulation into acupoint, namely BV acupuncture or Apipuncture, produced more potent anti-inflammatory and antinociceptive potency in rodent arthritis model as comparing with that of non-acupoint injection.

Based on previous report, we decided to further investigate that BV injection into an acupoint produces antinociception as a result of its potent chemical stimulatory effect in both abdominal stretch assay and formalin test. Different doses of BV were injected into an acupoint or a non-acupoint 30 min prior to intraplantar formalin injection or intraperitoneal acetic acid injection.

Using the abdominal stretch assay, we found that the high dose of BV (1:100 diluted in 20microl saline) produced a potent antinociceptive effect irrespective of the site of BV injection.

In contrast the antinociceptive effect observed in both the writhing and formalin tests following administration of a low dose of BV (1:1000 diluted in 20microl saline) was significantly different between acupoints and non-acupoint sites. BV injection into an acupoint (Zhongwan, Cv. 12) was found to produce significantly greater antinociception than non-acupoint injection (10 mm from Zhongwan, Cv. 12) in the abdominal stretch assay. Similarly, in the formalin test, acupoint (Zusanli, St. 36) injection of BV produced more potent antinociception than non-acupoint injection (gluteal muscle). In contrast, BV injection into an arbitrary non-acupoint site on the back did not produce antinociception in either the writhing or formalin test. These results indicate that BV injection directly into an acupoint can produce a potent antinociceptive effect and suggest that this alternative form of acupoints stimulation (Apipuncture) may be a promising method for the relief of pain.

PMID: 11394494

RESEARCH #17

If these researchers would just track the CRH and anti-inflammatory production changes caused by bee venom they could see where the positive effects of bee venom come from.

J Vet Med Sci.  2001 Mar;63(3):251-9.

Bee venom pretreatment has both an antinociceptive and anti-inflammatory effect on carrageenan-induced inflammation.

Lee JH, Kwon YB, Han HJ, Mar WC, Lee HJ, Yang IS, Beitz AJ, Kang SK.

Department of Veterinary Physiology, College of Veterinary Medicine, Seoul

National University, Suwon, South Korea.

Although the injection of bee venom (BV) has been reported to evoke tonic pain and hyperalgesia, there is conflicting evidence in the literature indicating that BV can also exert an anti-inflammatory and antinociceptive effects on inflammation. In this regard, BV has been traditionally used in Oriental medicine to relieve pain and to treat chronic inflammatory diseases such as

rheumatoid arthritis.

The present study was designed to test the hypothesis that BV induces acute nociception under normal conditions, but that it can serve as a potent anti-inflammatory and antinociceptive agent in a localized inflammatory state. The experiments were designed to evaluate the effect of BV pretreatment on carrageenan (CR)-induced acute paw edema and thermal hyperalgesia. In addition, spinal cord Fos expression induced by peripheral inflammation was quantitatively analyzed. In normal animals subcutaneous BV injection into the hindlimb was found to slightly increase Fos expression in the spinal cord without producing detectable nociceptive behaviors or hyperalgesia. In contrast pretreatment with BV (0.8 mg/kg) 30 min prior to CR injection suppressed both the paw edema and thermal hyperalgesia evoked by CR. In addition, there was a positive correlation between the percent change in paw volume and the expression of Fos positive neurons in the spinal cord.

These results indicate that BV pretreatment has both antinociceptive and anti-inflammatory effects in CR-induced inflammatory pain. These data also suggest that BV administration may be useful in the treatment of the pain and edema associated with chronic inflammatory diseases.

PMID: 11307924

RESEARCH #18

Raising the levels of blood CRH has several major direct and indirect positive effects on diabetes (the connection between low blood CRH and diabetes is a huge subject and will be covered in a future paper) There are two things of interest in this research summary. 1. Stimulating blood CRH just a few times has a positive effect on diabetes (Imagine how much good could be done by long term CRH replacement therapy) 2. There are things besides bee venom that strongly stimulate blood CRH.

J Korean Med Sci.  1999 Dec;14(6):648-52.

Effects of BCG, lymphotoxin and bee venom on insulitis and development of IDDM in non-obese diabetic mice.

Kim JY, Cho SH, Kim YW, Jang EC, Park SY, Kim EJ, Lee SK.

Department of Physiology, Yeungnam University College of Medicine, Taegu, Korea.

To investigate whether BCG, lymphtoxin (LT) or bee venom (BV) can prevent insulitis and development of diabetes in non-obese diabetic (NOD) mice, we measured the degree of insulitis and incidence of diabetes in 24 ICR and 96 female NOD mice. NOD mice were randomly assigned to control, BCG-, LT-, and BV-treated groups. The BCG was given once at 6 weeks of age, and LT was given in

3 weekly doses from the age of 4 to 10 weeks. The BV was injected in 2 weekly doses from the age of 4 to 10 weeks. Diabetes started in control group at 18 weeks of age, in BCG group at 24 weeks of age, and in LT- or BV-treated group at 23 weeks of age. Cumulative incidences of diabetes at 25 weeks of age in control, BCG-, LT-, and BV-treated NOD mice are 58, 17, 25, and 21%, respectively.

Incidence and severity of insulitis were reduced by BCG, LT and BV treatment. In conclusion, these results suggest that BCG, LT or BV treatment in NOD mice at early age inhibit insulitis, onset and cumulative incidence of diabetes.

PMID: 10642943

RESEARCH #19

The exposure to excessive UV light or X-rays is very damaging to the body and highly inflammatory. A very active HP>GAT axis protects the body and controls inflammation.

B19, B20, B21 and B22 are the shortest reports that demonstrate this.

Ann Pharm Fr.  1989;47(1):24-32.

[The effect of dilutions of Apis mellifica and Apium virus on ultraviolet light-induced erythema in the guinea pig]

[Article in French]

Bildet J, Guyot M, Bonini F, Grignon MC, Poitevin B, Quilichini R.

Dilutions of Apis mellifica (obtained from the whole bee) and Apium virus (obtained from bee venom) are used classically in homeopathy for inflammatory symptoms with edema, erythema and pruritus (Lewis triad). Using a method examining the evolution of UV induced erythema in the guinea pig, the authors show the following dilutions of Apis mellifica 7 CH(10(-14)), 9 CH(10(-18)) and of Apium virus 5 CH(10(-10)), 7 CH(10(-14)), 9 CH(10(-18)) exert an action on experimental erythema. The results are statistically significant for the dilutions at the 48th hour after irradiation.

PMID: 2627100

RESEARCH #20

Nippon Igaku Hoshasen Gakkai Zasshi.  1970 Mar;29(12):1494-500.

[Radioprotection by bee venom]

[Article in Japanese]

Kanno I, Ito Y, Okuyama S.

PMID: 5266622

RESEARCH #21

Nature.  1967 Jul 15;215(98):311-2.

Increased resistance of mice to x-irradiation after the injection of bee venom.

Shipman WH, Cole LJ.

PMID: 6059526

RESEARCH #22

Res Dev Tech Rep.  1967 Jan 11;:1-10.

Increased radiation resistance of mice injected with bee venom one day prior to exposure.

USNRDL-TR-67-4.

Shipman WH, Cole LJ.

PMID: 5298216

RESEARCH #23

The entire reproductive process is dependent upon a highly activated but tightly controlled immune system.  Everything from the preparation of the womb for pregnancy to the entire process of building the fetus is highly inflammatory and requires absolute control from the HP>GAT system.

These researchers probably don’t grasp the full importance of what they found.   In a normal healthy pregnancy the mother’s immune system recognizes the fetus as foreign DNA and builds a full set of antibodies to destroy that fetus.  The reason the baby is born healthy is because tight control from the HP>GAT system keeps the antibodies from going active and attacking.  Anytime the anti-inflammatory system response is insufficient to control these antibodies they will attack and destroy the fetus.  A high percentage of miscarriages are from this very reason.  Anything that will highly stimulate the anti-inflammatory system will provide the control to protect the fetus.

Since bee stings produce a high stimulation of the HP>GAT system they often will provide enough control to stop the mothers immune system from attacking the baby.  These researchers are correctly speculating that the immune rejection of the fetus is not because the immune system is highly stimulated but because there is insufficient anti-inflammatory controls what they call immuno-modulatory protein and that the bee venom is correcting this shortage.  The same thing can be done by anything increasing blood CRH.

The implications of this are monumental not only to increasing fertility in women with repeated miscarriages but in all manner of transplant patients.   Ask yourself this question what is the difference between the foreign DNA inside a mother and a transplanted heart, liver and etc.  Answer, nothing.  The immune system in both cases will recognize the foreign DNA and build antibodies to destroy it.   In a transplant patient they medically impair the immune system function so much in an effort to keep it from building antibodies that the patient is vulnerable to any kind of infection.   In a mother the immune system is not impaired but tightly controlled.  This protects the foreign DNA (the baby) yet leaves the immune system capable of fighting other disease.  In theory highly stimulating the HP>GAT/inflammatory control system with CRH in a transplant patient would allow the survival of the transplant without impairing the immune system ability to fight disease.

Wednesday, October 15, 2003

5:00 P.M.

O-290

Bee venom treatment of refractory pregnancy. A modern trend. Ali Ali, M. Mostafa, W. Hamed, A. Mekled. Ain Shams Univ, Cairo, Egypt.

Objective: To determine the role of bee venom injection in women who previously failed to achieve a successful pregnancy following at least 3IVF-ET cycles and if it would improve the chances of successful conception following another IVF-ET cycle. Design: Pregnancy after failed repeated 3 successive in vitro fertilization and embryo transfer-IVF-ET trials is a striking subject and to the best of our knowledge, no report in the literature has dealt with this topic.

It has been suggested that an increase in the Natural Killer cell percentage in the blood or increase in NK cell activity in the endometrium can cause embryo/fetal destruction. Trying to negate these adverse effects was warranted. We have found that bee venom due to its peculiar chemical composition can offer a solution for this problem. Our own speculation is that immune rejection is more related, not to a cellular immune system that is always over-stimulated, but rather to a failure to secrete sufficient immuno-modulatory protein after trophoblast invasion which inhibits what should be a normal immune response to allograft.

Materials and Methods: Seven cases were enrolled in this study. Criteria for selection were previous failure to have a successful pregnancy after, at least, 3 or more attempts of IVF-ET. Patients were referred from different centers. Two cases had failed 5 attempts, 4 had failed 4 attempts and one case failed after 3 attempts. Mean age was 38.2_2.1. Bee venom therapy was started for 2 weeks every other day (0.1 ml SC Farid ampoule-first author of this study). Following this, another IVF-ET attempt was done. Results: Four cases got pregnant (57.1%): 2 from failed previous 4 attempts, one case from failed previous 5 attempts and one from failed previous 3 attempts. Live births rate was 3 cases (75%). One case aborted at 6 weeks of pregnancy.

Conclusion: These data revealed that bee venom therapy can stimulate post-implantation immuno-stimulatory protein, opening a new horizon in the field for improvement of results of IVF-ET. However, this should be confirmed by a randomized prospective trial.

[reference: http://tnymed.com/?p=271]

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